Altered element homeostasis and transmethylation ability in short-term polyphenol rich supplementation in hyperlipidemic animal model

Abstract Non-alcoholic fatty liver disease is one of the most common chronic diseases with unclarified pathomechanism and without evidence-proven therapy. Dietary polyphenols, targeting oxidative stress, are at center investigations. Our aim was to examine effects a polyphenol rich extract on metal element homeostasis transmethylation ability in non-alcoholic model. A ten-day rat model used (control group, hyperlipidemic group fat-rich diet, diet supplementation, N = 8 each group). The increased concentration majority elements significantly higher contents B, Co, Cu, Fe, Mg, Mn, Na, Ni, P, Se, Si, Zn liver. Further elevation Al, Pb, Sn concentrations could be observed supplemented animals. supplement unexpectedly decreased (132.00 vs. 114.15 92.25 HCHO μg g −1 ) further. results emphasize possible role altered non-metal disease. supplementation natural compounds may have undesirable effect as well, there necessity improve efficacy formulations because their low oral bioavailability.